RED DE BIOETICA
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Volume
30
CONTENTS EDITORIAL The EU White Paper:
Strategy fora Future Chemicals Policy (an idea that must have seemed good
at the time!) NEWS & VIEWS ARTICLES Alternatives to animal
testing in the safety evaluation of products. A comparative study
of the toxicity of mercury dichloride and methylmercury, assayed by the
frog embryo teratogenesis assay-Aenopus (FETAX). Use of a cell transformation
assay with established cell fines, and a metabolic cooperation assay with
V79 cells for the detection of tumour promoters: a review. Cystathionine pathway-dependent
cytotoxicities of diethyl maleate and diamide in rat and human hepatoma-derived
cell cultures. Cytostatic properties
of a novel compound derived from Penicillium pinophilum: an in vitro study.
Detection of the embryotoxic
potential of cyclophosphamide by using a combined system of metabolic
competent cells and embryonic stem cells. Use of the SOS-chromotest
spot assay as a screening system for detecting genotoxic compounds in
crude plant extracts. Comparative evaluation
of five in vitro tests for assessing the eye irritation potential of hair-care
products. ECVAM's contributions
to the implementation of the Three Rs in the production and quality control
of biologicals. ECVAM Task Force Report
COMMENT A critique of the
Animal Procedures Committee report on biotechnology SELECTED
TITLES Volume
30, Number 2 CONTENTS EDITORIAL Replacing animal experimentation:
not a question of if, but when, and by what route? ARTICLES The ECVAM international
validation study on in vitro embryotoxicity tests: results of the definitive
phase and evaluation of prediction models. Selection of test
chemicals for the international validation study on in vitro embryotoxicity
tests. Losartan decreases
glomerular filtration rate in isolated perfused porcine slaughterhouse
kidneys. In vitro setting of
dose-effect relationships of 32 metal compounds in the Balb/3T3 cell line,
as a basis for predicting their carcinogenic potential. The use of fetal bovine
serum: ethical or scientific problem? Possibilities of replacing
and reducing animal tests in the pharmacopoeias: an evaluation of unused
methods and proposals for change. Two in vitro models
for gas-phase exposure to volatile compounds. CONFERENCE DIARY SELECTED TITLES Volume
30, Number 3 CONTENTS EDITORIAL Alternatives to animal
experiments: "goodbye ECVAM, hello FRAME" ECVAM NEWS & VIEWS ARTICLES Organotypic brain-slice
cultures from adult rats: approaches for a prolonged culture time. Evaluation of a rule
base for identifying contact allergens by using a regulatory database:
comparison of data on chemicals notified in the European Union with "structural
alerts" used in the DEREK Expert System. Is it possible to
replace stimulus animals by scent-filled cups in the social discrimination
test?. The Ninteenth Workshop
of the Scandinavian Society for Cell Toxicity Cytotoxicity of amino
alcohols to rat hepatoma-derived Fa32 cells. Development of an
in vitro test battery for the estimation of acute human systemic toxicity:
an outline of the EDIT project. Morphology of cell
injury: an approach to the EDIT programme by the use of tobacco pollen
tubes. The comet assay with
MCL-5 cells as an indicator of genotoxic treatment with chemicals and
cigarette smoke condensate. Chemical tests as
alternatives to animal tests in research on late symptoms in diabetes.
LETTER BOOK REVIEWS SELECTED TITLES Volume
30, Number 4 CONTENTS EDITORIAL Alternatives to animal
experiments: producing the fruits ARTICLES An assessment of progress
in the use of alternatives in toxicity testing since the publication of
the report of the Second FRAME Toxicity Committee (1991). ECVAM TASK FORCE REPORT
In vitro phototoxicity
testing -- development and validation of a new concentration response
analysis software and biostatistical analyses related to the use of various
prediction models. A method for the in
vitro exposure of human cells to environmental and complex gaseous mixtures:
application to various types of atmosphere. Stable biocompatible
adjuvants -- a new type of adjuvant based on solid lipid nanoparticles:
a study on cytotoxicity, compatibility and efficacy in chicken The implications of
microarray technology for animal use in scientific research BOOK REVIEWS SELECTED TITLES Volume
30, Number 5 CONTENTS EDITORIAL Animal experiments:
are there no limits? ECVAM NEWS & VIEWS ARTICLES The prediction of
human skin responses by using the combined in vitro fluorescein leakage/Alamar
Blue (resazurin) assay. Evaluation of a porcine
lens and fluorescence assay approach for in vitro oclular toxicological
investigations. Long-term in vitro
toxicity models: comparisons between a flow-cell bioreactor, a static-cell
bioreactor and static cell cultures. Three-dimensional
co-culture of primary human liver cells in bioreactors for in vitro drug
studies: effects of the initial cell quality on the long-term maintenance
of hepatocyte-specific functions. A comparison of ecotoxicological
tests Comments on the use
of bootstrap resampling to assess the uncertainty of Cooper statistics
SELECTED TITLES Volume
30, Supplement 2 CONTENTS PREFACE INTRODUCTION The importance of
ECVAM The establishment
of ECVAM and its progress since 1993 The principles of
validation and the ECVAM validation process The Interagency Coordinating
Committee on the Validation of Alternative Methods (ICCVAM): a review
of the ICCVAM test method evaluation process and current international
collaborations with the European Centre for the Validation of Alternative
Methods (ECVAM) Validation successes:
chemicals ECVAM's role in the
implementation of the Three Rs concept in the field of biologicals Comparison and validation
of novel pyrogen tests based on the human fever reaction Transepithelial resistance
and inulin permeability as endpoints in in vitro nephrotoxicity testing
ECVAM's activities
in validating alternative tests for skin corrosion and irritation Ocular safety: a silent
(in vitro) success story In vitro tests for
haematotoxicity- prediction of drug-induced myelosuppression by the CFU-GM
assay The current status
and future applicability of quantitative structure-activity relationships
(QSARs) in predicting toxicity The necessity of biokinetic
information in the interpretation of in vitro toxicity data Selected biostatistical
aspects of the validation of in vitro toxicological assays Barriers, nephrotoxicology
and chronic testing in vitro Development of a testing
strategy for detecting embryotoxic hazards of chemicals in vitro by using
embryonic stem cell models Haematotoxicology:
scientific basis and regulatory aspects Metabolism and neurotoxicity:
the significance of genetically engineered cell lines and new three-dimensional
cell cultures ECVAM's research and
validation activities in the fields of topical toxicity and human studies
ECVAM's activities
on biologicals Genomics: an in vitro
toxicology point of view ECVAM's activities
on computer modelling and integrated testing The ECVAM Scientific
Information Service (SIS) Information: needs
for the future The ECVAM workshops:
a critical assessment of their impact on the development, validation and
acceptance of alternative methods ECVAM: desperately
needed or superfluous? An animal welfare perspective ECVAM's collaboration
with academia ECVAM, ECETOC and
the EU chemicals policy The contributions
of the European cosmetics industry to the development of alternatives
to animal testing: dialogue with ECVAM and future challenges Dialogue and collaboration
with ECVAM: the view of the EFPIA ecopa: a powerful
concept in the way forward for alternative methods ECVAM'S activities
in the EU candidate countries Dialogue and collaboration:
a personal view on laboratory animal welfare developments in general,
and on ECVAM's first decade in particular The EC White Paper
on a Strategy for a Future Chemicals Policy The Seventh Amendment
to the Cosmetics Directive: what does DG Enterprise want from ECVAM? Directive 86/609/EEC
on the protection of animals used for experimental and other scientific
purposes ECVAM and pharmaceuticals
Future activities:
ECVAM and the quality control of biologicals ECVAM-ICCVAM: prospects
for future collaboration The future of ECVAM:
a personal perspective ECVAM Status Seminar
2002: closing remarks Volume
29, Number 1 CONTENTS EDITORIAL ANDi: "Now, God
help thee, poor monkey!" OBITUARY Björn Ekwall
MD ARTICLES Indirect cytotoxicity
of dental materials: a study with transwell inserts and the neutral red
uptake assay. Application of modelling
techniques to the planning of in vitro arsenic kinetic studies. Effects of L-proline
on phase I and phase II xenobiotic biotransformation capacities of rat
and human hepatocytes in long-term collagen gel cultures. Ethical investment
-- what is it, and what are the implications for industry funding of research
into alternatives? Mutagenesis screens:
can they be justified? BOOK REVIEW Laboratory animal law / Dictionary of toxicology -- second edition / The world of instinct / Toxicity assessment alternatives: methods, issues, opportunities / Progress in the reduction, refinement and replacement of animal experimentation. Developments in animal and veterinary science. SELECTED TITLES Volume
29, Number 2 CONTENTS EDITORIAL Why the US Department
of Agriculture should be allowed to insist on inclusion of rodents and
birds in the Animal Welfare Act ECVAM NEWS & VIEWS ARTICLES ECVAM Workshop Reports
The establishment
of human research tissue banking in the UK and several western European
countries. The importance of
the prediction model in the validation of alternative tests. The red blood cell
phototoxicity test (photohaemolysis and haemoglobin oxidation): EU/COLIPA
validation programme on phototoxicity (phase II). Toxic effects of chromium
acetate hydroxide on cells cultivated in vitro. Collagen type I gell
cultures of adult rat hepatocytes as a screening induction model for cytochrome
P450-dependent enzymes. COMMENT Commmunication
of the Three Rs within establishments: some problems and solutions: report
of a LASA Alternatives Section meeting
CONTENTS EDITORIAL Scientific progress
and animal welfare: conflicting goals or complementary opportunities?
ARTICLES The Eighteenth Workshop of the Scandinavian Society for Cell Toxicology Obituary: Cytotoxicity of the
MEIC reference chemicals in antioxidant-enriched rat hepatoma-derived
Fa32 cells. The use of cultured
hepatocytes to investigate the metabolism of drugs and mechanisms of drug
hepatotoxicity. The DRAG test: an
assay for detection of genotoxic damage. Caspase-3 activity
and carbonyl cyanide m-chlorophenylhydrazone-induced apoptosis in HL-60
cells. Metabolic activity
in primary cultures of fish hepatocytes. Study of the environmental
hazard caused by the oil shale industry solid waste. Cytotoxicity testing
of wound-dressing materials. Biochemical responses
in aquatic plants as markers of environmental contamination. Extended Abstracts: The formation of free
radicals in human granulocytes and cerebellar granule cells. Molecular profiling
and prediction of toxicity. Multivariate modelling
of polychlorinated biphenyl-induced CYP1A activity in the MH1C1 rat hepatoma
cell line. Long-term in vitro
toxicity of 27 MEIC chemicals on Hep G2 cells. Preliminary results
of the ECVAM validation study on three in vitro embryotoxicity tests.
Integration of in
vitro approaches to predict drug metabolism and interaction in man: an
EU validation project. Test validation: from
animal data comparison to prospective evaluation. Protein precipitation
in vitro as a measure of chemical-induced cytotoxicity: an EDIT sub-programme.
Uniform expression
of alcohol dehydrogenase 3 in epithelia regenerated with cultured normal,
immortalised and malignant human oral keratinocytes. Pyruvate-induced long-term
maintenance of glutathione S-transferase in rat hepatocyte cultures. A compartment model
to calculate time-dependent concentration profiles of topically applied
chemical compounds in the anterior compartments of the rabbit eye. COMMENT A major initiative
from the European pharmaceutical industry and ECVAM. BOOK REVIEWS Chicken egg yolk antibodies,
production and application, IgY-technology / Animal experimentation: a
guide to the issues Volume
29, Number 4 CONTENTS EDITORIAL Animal procedures
remain vital to biomedical research: it ain't necessarily so ECVAM NEWS & VIEWS ARTICLES ECVAM Workshop Report
W. Pfaller, M. Balls, R. Clothier, S. Coecke, P. Dierickx, B. Ekwall, B.A. Hanley, T. Hartung, P. Prieto, M.P. Ryan, G. Schmuck, D. Sladowski, J-A. Vericat, A. Wendel, A. Wolf & J. Zimmer Guidelines for the
design and statistical analysis of experiments in papers submitted to
ATLA. The use of bootstrap
resampling to assess the uncertainty of Cooper statistics. Lead inhibits growth
and induces apoptosis in normal rat fibroblasts. The current status
of food additives toxicity testing and the potential for application of
the Three Rs. In Vitro Toxicology
Industrial Platform (IVTIP) position paper, 9 February 2001: the role
of an industrial platform in the area of in vitro testing. Summary: EU standards
measurements and testing project PL95-3407. Development of a standardised
in vitro methodology for hepatic and renal toxicity testing. CONFERENCE DIARY BOOK REVIEW Pain: its nature and
management in man and animals Humane endpoints --
lethal parameters: humane endpoints replace lethal parameters in batch
potency tests of rabies vaccines Volume
29, Number 5
CONTENTS EDITORIAL Increased use of human
cell lines: yet more skeletons in the cupboard? ECVAM NEWS & VIEWS ARTICLES The role of ECVAM
in promoting the regulatory acceptance of alternative methods in the European
Union. Co-occurring words
and retrieval efficiency: finding information about alternatives to animal
testing in relation to skin irritation testing. Evaluation of the
toxicity of substituted benzthioanilides by using in vitro tests. The use of bootstrap
resampling to assess the variability of Draize tissue scores. The neutral red release
assay: a review. In vitro assessment
of cytotoxicity and carcinogenic potential of chemicals: evaluation of
the cytotoxicity induced by 58 metal compounds in the Balb/3T3 cell line.
CONFERENCE DIARY BOOK REVIEW Sacred cows and golden
geese / New microbiotests for routine toxicity screening Volume
29, Number 6 CONTENTS EDITORIAL Attitudes to alternatives
to Animal Experimentation FRAME ANNUAL LECTURE International cooperation:
an essential requirement for replacing animal toxicity tests. ECVAM Workshop Report
Comparative evaluation
of five in vitro tests for assessing the eye irritation potential of hair-care
products. Electrical stimulation
of transforming grwoth factor-ß1 secretion by human dermal fibroblasts
and the U937 human monocytic cell line. A genetically engineered
cell-based system for detecting metabolism-mediated toxicity. Human haemoclassification
by use of specific yolk antibodies obtained after immunisation of chickens
against human blood group antigens. The impact of the
introduction of the Ethical Review Process for research using animals
in the UK: attitudes to alternatives among those working with experimental
animals. COMMENT In vitro toxicology
in the light of new technologies SELECTED TITLES AUTHOR INDEX SUBJECT INDEX
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