RED DE BIOETICA
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(Alternatives To Laboratory Animals) Volume
28 Volume
28, Number 1 CONTENTS THE THREE RS DECLARATION OF BOLOGNA Reduction, refinement
and replacement alternatives and laboratory animal procedures ARTICLES Development of a decision
support system for the introduction of alternative methods into local
irritancy/corrosivity testing strategies. Development of a relational
database. Local irritation/corrosion
testing strategies: development of a decision support system for the introduction
of alternative methods. Testing wound-healing
activity in T15 fibroblast cultures: a morphometric analysis. Development of a gill
perfusion apparatus for studying the interaction of fish pathogens with
gill tissue. Evaluation of various
immunisation procedures in laying hens to induce high amounts of specific
egg yolk antibodies. Endocrine disruptors:
a critical review of in vitro and in vivo testing strategies for assessing
their toxic hazard to humans. ECVAM Workshop Report
COMMENT Developments in the
collection of statistical information on the number of animals used in
experiments and other scientific purposes in the European Union. BOOK REVIEWS Ethics, animals and
science. SELECTED TITLES Volume
28, Number 2 CONTENTS EDITORIAL The safe and ethical
supply of human tissues for in vitro studies NCA LETTER ARTICLES ECVAM Workshop Report
The Peterborough Hospital
Human Tissue Bank. The high production
volume chemical challenge program: the rodent LD50 and its possible replacement.
Methyl green-pyronine
staining of porcine organotypic skin explant cultures: an alternative
model for screening for skin irritants. A comparison of three
cytotoxicity endpoints in the corneal HCE-T model. Conceptualisation
of diagnostic agents: from empirical in vivo screening to rational in
vitro predictive parameters. Volunteers in Research
and Testing Workshop Report COMMENT FRAME's response to
an APC questionnaire on emerging biotechnologies and the Animals (Scientific
Procedures) Act 1986. Abstracts of the articles
published in ALTEX Volume 16, 1999. BOOK REVIEWS Genetic engineering and animal welfare. Volume
28, Number 3 CONTENTS EDITORIAL Testing biocides --
will common sense prevail? The ECVAM prevalidation
study on the use of EpiDerm for skin corrosivity testing. Structure-permeability
relationships for transcorneal penetration. In vitro cytotoxicity
of four different buffers for use in peritoneal dialysis. Iron-induced lipid
peroxidation in human skin-derived cell lines: protection by a red orange
extract. The Seventeenth Workshop
of the Scandinavian Society for Cell Toxicology Activities of glutathione
S-transferase and glutathione peroxidases related to diet quality in an
aphid predator, the seven-spot ladybird, Coccinella septempunctata L.
(Coleoptera: Coccinellidae). A new mechanism of
mammalian cell resistance to the toxic effects of DNA-binding agents.
Gill epithelial cells
as in vitro models in aquatic toxicology. Toxicological investigation
of soils with the soild-phase flash assay: Comparison with other ecotoxicological
tests. Cytotoxicity of cadmium,
selenium, zinc and copper to mouse myeloma Sp2/0 cells as measured by
the MTT assay. Retinal Müller
cell culture. Surface-adhering human
leucocytes: an in vitro model for cytotoxicity testing of fluids. Toxicity testing of
polymer materials for dialysis equipment: reconsidering in vivo testing.
Host plant effects
on activities of detoxification enzymes and insecticide tolerance in western
flower thrips. Frankliniella occidentalis (Insecta). Toxicological evaluation
of surface-water samples in sensitised cultured fish cells compared with
the Microtoxµ method.
Comments on the European
Community strategy for endocrine disruptors. Application of the
Three Rs principle in the compilation of "Technical Guidance Document
in Support of Directive 98/8/EC Concerning the Placing of Biocidal Products
on the Market. Part I. Guidance on Data Requirements for Active Substances
and Biocidal Products." AROUND THE WORLD Spanish Activities
on Alternatives BOOK REVIEWS Handbook
of laboratory animal management and welfare / Neurotoxicology in vitro
/ General and Applied Toxicology Volume
29, Number 4 CONTENTS EDITORIAL Animal procedures
remain vital to biomedical research: it ain't necessarily so ECVAM NEWS & VIEWS ARTICLES ECVAM Workshop Report
W. Pfaller, M. Balls, R. Clothier, S. Coecke, P. Dierickx, B. Ekwall, B.A. Hanley, T. Hartung, P. Prieto, M.P. Ryan, G. Schmuck, D. Sladowski, J-A. Vericat, A. Wendel, A. Wolf & J. Zimmer Guidelines for the
design and statistical analysis of experiments in papers submitted to
ATLA. The use of bootstrap
resampling to assess the uncertainty of Cooper statistics. Lead inhibits growth
and induces apoptosis in normal rat fibroblasts. The current status
of food additives toxicity testing and the potential for application of
the Three Rs. In Vitro Toxicology
Industrial Platform (IVTIP) position paper, 9 February 2001: the role
of an industrial platform in the area of in vitro testing. Summary: EU standards
measurements and testing project PL95-3407. Development of a standardised
in vitro methodology for hepatic and renal toxicity testing. CONFERENCE DIARY BOOK REVIEW Pain: its nature and
management in man and animals Humane endpoints --
lethal parameters: humane endpoints replace lethal parameters in batch
potency tests of rabies vaccines Volume
28, Number 5 CONTENTS EDITORIAL Drunken monkeys and
cruel humans ARTICLES The isolated perfused
bovine udder as a model of dermal eicosanoid release. Local irritation/corrosion
testing strategies: extending a decision support system by applying self-learning
classifiers. Development of a decision
support system for the introduction of alternative methods into local
irritancy/corrosivity testing strategies. Creation of fundamental rules
for a decision support system. The humoral immune
response and the productivity of laying hens kept on the ground or in
cages. An evaluation of mechanistic
in vitro tests for the discrimination of photoallergic and photoirritant
potential
SELECTED TITLES Volume
28, Number 6 CONTENTS EDITORIAL Promoting the Three
Rs: Actions speak louder than words European Science Foundation
policy briefing: use of animals in research FRAME ANNUAL LECTURE The Three Rs: A journey
or a destination ECVAM Workshop Report
Replacement of fetal
calf serum in cell cultures by an egg yolk factor with cholecystokinin/gastrin-like
immunoreactivity. Cultured porcine urinary
bladder epithelial cells as a screening model for genotoxic effects of
aromatic amines: Characterisation and application of the cell culture
model. COMMENT Bibliometric analysis
of the performance of ATLA: An update. In vitro preclinical
lead optimisation technologies (PLOTs) in pharmaceutical development.
Regulation of the
use of animals in research in Poland, and the development of alternatives.
CONFERENCE REPORT CONFERENCE DIARY BOOK REVIEW The UFAW handbook on the care and management of laboratory animals. SELECTED TITLES AUTHOR INDEX SUBJECT INDEX CONTENTS EDITORIAL The precautionary
principle should be used with caution -- and should be applied to animal
experimentation and genetic manipulation, not merely to protection of
the environment ECVAM NEWS & VIEWS 3RD WORLD CONGRESS LETTER FROM CAAT ARTICLES ECVAM Workshop Report
Eye irritation testing:
the way forward. The production of
polyclonal antibodies in laboratory animals. Comparative surfactant
reactivity of canine and human stratum corneum: a plea for the use of
the corneosurfametry bioassay. A preliminary comparison
of LiverBeadsTM with a conventional rat hepatocyte culture preparation:
some aspects of xenobiotic metabolism and related toxicity. Short-term toxicity
of various pharmacological agents on the in vitro nitrification process
in a simple closed aquatic system. Human bone marrow
cell culture: A sensitive method for determination of the biocompatibility
of implant materials. Cats in scientific
procedures: main areas of use in the UK and some causes for concern. A general approach
for evaluating stepwise testing strategies. Abstracts of the articles
published in ALTEX Volume 15 1998 BOOK REVIEWS Animal alternatives,
welfare and ethics AUTHOR INDEX SUBJECT INDEX Volume
27, Number 2 CONTENTS EDITORIAL Seeking information
on the Three Rs -- more than just a legal burden ECVAM NEWS & VIEWS 3RD WORLD CONGRESS LETTER FROM CAAT ARTICLES ECVAM Task Force Report
Accessing information
on the reduction, refinement and replacement of animal experiments. Report
and recommendations of a Focus on Alternatives workshop. The use of human keratinocytes
in the EU/COLIPA international in vitro phototoxicity test validation
study and the ECVAM/COLIPA study on UV filter chemicals. Selection induction
of interleukin-12 in reconstructed human epidermis by chemical allergens.
Alternative methods
for assessing biocompatability and function of implant materials. Lack of effect of
medium supplementation with pyruvate and hormones on cytochrome P450-mediated
activity of rat hepatocytes in primary culture. Implementation of
the Three Rs targets in the EU, in science and in industry CONFERENCE DIARY BOOK REVIEWS Animal alternatives,
welfare and ethics Volume
27, Number 3 CONTENTS EDITORIAL New measures on animal
experimentation in the UK will improve animal welfare and scientific research.
3RD WORLD CONGRESS LETTER FROM THE NCA ARTICLES Joint Congress of
the Scandinavian Society of Cell Toxicology and the Estonian Society of
Toxicology EDIT: a new international
multicentre programme to develop and evaluate batteries of in vitro tests
for acute and chronic systemic toxicity. The effects of oxidative
stress in in vitro cultured astroglial cells. Predicting the toxicity
of oi;-shale industry wastewater by its phenolic composition. Can cytotoxic effects
induced by industrial chemicals be time-dependent? Phytotoxicities of
selected chemicals and industrial effluents to Nitellopsis obtusa cells,
assessed by using a rapid electrophysiological charophyte test. Oxidative DNA damage
in human cells induced by paraquat. Toxicity of mercury
to hybridoma TA7 cells. Apoptosis versus cytotoxicity
in HeLa cells exposed to paracetamol. Volatile organic compounds
in Tartu office buildings. Retinal pigment epithelial
cell cultures as a tool for evaluating retinal toxicity in vitro. Use of the Daphnia
magna test to estimate the toxicity of the ozonation by-products of phenols
and chlorophenols. Evaluation of a short-term
rat proximal tubule incubation for the detection of nephrotoxicants. In vitro testing of
the responses of human gingival fibroblasts and L-929 cells to nicotine.
The use of a germination
bioassay as a toxicological screening system to study the potential drug-drug
interactions of (S)-naproxen and (s)-ibuprofen and their corresponding
oxidative state analogues, (S)-naproxol and (S)-ibuprofen alcohol. Establishment of an
embryotoxicity assay with green fluorescence protein-expressing embryonic
cell-derived cardiomyocytes. AROUND THE WORLD Launch of the Belgian
Platform for Alternative Methods BOOK REVIEWS Improving nature.
Volume
27, Number 4 CONTENTS EDITORIAL Animal experiments:
letting the people speak. 3RD WORLD CONGRESS CAAT LETTER ARTICLES ECVAM Workshop Reports
The Principles of
Good Laboratory Practice: application to in vitro toxicology studies.
ECVAM Task Force Report
In vitro alternatives
and phototoxicity testing. I. Evaluation of in vitro phototoxicity assays.
In vitro alternatives
and phototoxicity testing. II. Effects of reactive oxygen species in in
vitro phototoxicity assays. An interlaboratory
validation study of the improved transformation assay employing Balb/c
3T3 cells: results of a collaborative study on the two-stage cell transformation
assay by the Non-genotoxic Carcinogen Study Group. CONFERENCE REPORT CONFERENCE DIARY BOOK REVIEWS The use of immuno-adjuvants
in animals in Australia and New Zealand. Volume
27, Number 5 CONTENTS EDITORIAL What's in a name?
Opacity and transparency and animal-based research ARTICLES ECVAM Workshop Reports
Cell transformation
assays as predictors of human carcinogencity. Comparison of hepatocyte
cultures and liver slices in in vitro toxicity testing. Time-courses of growth
inhibition and recovery for narcotic chemicals and 2,6-dinitrophenol in
pollen suspensions of Nicotiana sylvestris. COMMENT Laboratory animal
consciousness and feelings: adopting the precautionary principle. CONFERENCE DIARY BOOK REVIEWS Occupational health
and safety in the care and use of research animals / Attitudes to animals:
views in animal welfare.
CONTENTS Preface: Does the
use of transgenic animals raise particular welfare and ethical concerns?
ECVAM Workshop Report
28: The use of transgenic animals in the European Union. ECVAM workshop 28:
a research perspective (Comment). ECVAM workshop 28:
an industry perspective (Comment). Do Canadian Council
on Animal Care guidelines meet ECVAM recommendations on transgenic animals?
(Comment) Transgenic models
for prion disease: have they outlived their useful purpose? Transgenic mouse bioassays
for carcinogenicity testing: a step in the right direction? Bioethical issues
in the generation and use of transgenic farm animals. Welfare assessment
of transgenic animals: behavioural responses and morphological development
of newborn mice. A proposal for a new
ethical scheme addressing the use of laboratory animals for biomedical
purposes. New
guidance notes for projects generating or maintaining genetically modified
animals (Comment). CONTENTS EDITORIAL Precautions and claims
for "safety" based on inadequate risk assessment are hazardous
and expose all concerned to risk FRAME ANNUAL LECTURE Professor W.M.S. Russell
Gastrulating Rat Embryo
in a Serum-free Culture Model: Changes of Development Caused by Teratogen
5-Azacytidine. Description of a dynamic
in vitro model of the dog gastrointestinal tract and an evaluation of
various transit times for protein and calcium. Effects of chromatin
function inhibitors on yeast whole cells and spheroplasts. Determination of the
starting dose for acute oral toxicity (LD50) testing in the Up and Down
Procedure (UDP) from cytotoxicity data. COMMENT Laboratory animal
consciousness and feelings: adopting the precautionary principle. CONFERENCE DIARY BOOK REVIEWS Occupational health
and safety in the care and use of research animals / Attitudes to animals:
views in animal welfare.
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