RED DE BIOETICA
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Volume
24
Volume
24, Number 1 CONTENTS EDITORIAL Current progress in
the validation of alternative test methods LETTER FROM CAAT ARTICLES Intestinal motility:
a computer simulation of the effects of drugs on colonic peristalsis,
for teaching undergraduate pharmacology students. The development of
corneal opacity, increased hydration and increased thickness in isolated
porcine corneas in response to timolol maleate solutions containing various
preservatives. A comparison of hepatic
enzyme activities and their modulation by dexamethazone in freshly isolated
and cultured hepatocytes and in the differentiated hepatoma cell lines,
2sFou. Toxicity of bread
wheat lines lacking prolamins encoded by the Gli-B1/Bli-B5/Glu-B3 and
Gli-D1/Glu-D3 loci in coeliac disease as determined by their agglutinating
activity. Application of statistical
classification methods to the evaluation of in vitro tests. Determination of phosphofructokinase
and enolase activities in cultured mouse neuroblastoma cells: application
to the in vitro detection of neurotoxic effects. The development and
interlaboratory validation of a quantitative antibody capture ELISA for
the measurement of specific guinea-pig IgG1: an alternative to the passive
cutaneous anaphylaxis assay. ECVAM Workshop Report
Alternative methods
and cosmetic testing The production of
monoclonal antibodies: are animals still needed? Regulatory toxicity
testing and the Animals (Scientific Procedures) Act 1986 CONFERENCE DIARY BOOK REVIEWS Animal genetic engineering:
of pigs, oncomice and men / Photobiology / Laboratory animals: an introduction
for experimenters / Planning and managing dissection laboratories / Finding
out... about animals in medicines research / Experimental toxicology:
the basic issues Volume
24, Number 2 CONTENTS EDITORIAL No prediction model,
no validation study ECVAM NEWS & VIEWS LETTER FROM CAAT ARTICLES The Three Rs in research
and education: a long road ahead in the United States. The Fifth Meeting of the Netherlands In Vitro Toxicology Group and the Netherlands Alternatives to Animal Experiments Platform. The use of porcine
proximal tubular cells for studying nephrotoxicity in vitro: the role
of oxidative stress in cisplatin-induced cell death. Relevance of animal
studies in regulatory toxicology: current approaches in rats. In vitro-based and
in vivo-based simulations of benzene uptake and metabolism in rats. Direct functional
effects of parathion and paraxon on neuronal nicotinic and muscarinic
M3 acetylcholine receptors. An interlaboratory
evaluation of five pairs of teratogens and non-teratogens in post-implantation
rat embryo culture. ECVAM Workshop Report
CONFERENCE DIARY BOOK REVIEWS Animal welfare: a
cool eye towards eden / Studies in research ethics: Vols. 5 & 6 /
The animal research controversey. Protest, process & public policy:
an analysis of strategic issues / The status on alternative methods in
toxicology Volume
24, Number 3 CONTENTS EDITORIAL Rex Leonard Burch
(1926-1996) LETTER FROM CAAT ARTICLES
Dynamic qualities
of validation and the evolution of new in vitro toxicology tests. Validation of in vitro
tests in neurotoxicology. An in vitro model
of the blood-brain barrier: The response of Madin-Darby canine kidney
cells to triethyl tin. In vitro studies of
acrylamide neurotoxicity in rat pheochromocytoma (PC12) cells. Nicotinic receptors
of different species exhibit differential sensitivities to nitromethylene
and organophosphate insecticides. Exposure of cultured
microglial cells to interferon-gamma. Cholingergic and glutaminergic
excitation of neuronal cells. The use of isolated
hepatocytes from rats with enzyme-altered foci: studies of p53 expression.
The influence of glutathione
on the cytotoxicity of metals in rat hepatoma-derived Fa32 cells. Detection of oxidised
purines and UV-induced photoproducts in DNA of single cells, by inclusion
of lesion-specific enzymes in the comet assay. In vitro cytotoxicity
testing of potentially active anti-HIV drugs with cultured cells. Environmental genotoxicity
in an Estonian oil shale industrial area. Fluorescent probes
as tools in in vitro toxicology. Main features of basal
cytotoxicity: sites of toxic action and interaction in the pollen tube
cell. In vitro toxicology
and the test guidelines. CONFERENCE DIARY BOOK REVIEWS The validation of
replacement alternative methods / In vitro toxicology / Animals, property
and the law / Animals and why they matter Volume
24, Number 4 CONTENTS EDITORIAL No statistics, no
science -- let alone validation studies Lord Houghton of Sowerby
ECVAM NEWS & VIEWS LETTER FROM CAAT ARTICLES
ECVAM Workshop Report
Acute toxicity testing
in vitro and the classification and labelling of chemicals. ECVAM Taskforce Report
The Second Conference
of CellTox The capacity of murine
epithelial cell lines with different degrees of malignant transformation
to metabolise benzo[a]pyrene. Effects of cereal
prolamin peptides on differentiated CaCo-2 cells. Reactive oxygen species
measured from suspensions of polymorphonuclear leukocytes after the addition
of silicon carbide particles. Prooxidant agents
induce modifications in the cytoskeletal organisation of fibroblasts.
DT-diaphorase affects
the mutagenic activity of pyrene 1,6-quinon in Chinese hamster epithelial
liver (CHEL) cells. In vitro cytotoxicity
testing of a candidate drug delivery material. The human leukemic
HL-60 cell line: an in vitro model for cell death endpoint identifications.
Effects of benomyl
on cytochrome P450 monooxygenase systems in the Hep G2 cell line. A cytogenetic approach
to the study of genotoxic effects of fungicides: an in vitro study in
lymphocyte cultures with thiophanate-methyl. Role of Phase II enzymes
in the bioactivation of 1,4-dichlorobenzene and 1,4-dibromobenzene. AROUND THE WORLD LETTER CONFERENCE REPORTS CONFERENCE DIARY BOOK REVIEWS Aping science: a critical analysis of research at the Yerkes Regional Primate Research Center / Toxicology of contact hypersensitivity / The UFAW handbook on the care and management of decapod crustaceans in captivity SOFTWARE REVIEW SELECTED TITLES Volume
24, Number 5 CONTENTS EDITORIAL The first ten years
of the Animals (Specific Procedures) Act 1986 ECVAM NEWS & VIEWS LETTER FROM CAAT ARTICLES
In vitro tests for
respiratory toxicity. Alternative methods
for skin sensitisation testing. An interactive computer
program to replace in vivo experiments on rat blood pressure for teaching
undergraduate students. Cytotoxic effects
of paracetoamol in vitro: the effects of an S9 fraction. Measurement of xenobiotic
metabolising enzyme activities in primary monolayer cultures of immature
rainbow trout hepatocytes at two acclimatisation temperatures. Results of a validation
study in Germany on two in vitro alternatives to the Draize eye irritation
test, the HET-CAM test and the 3T3 NRU cytotoxicity test. SHORT NOTE Effects of surfactant
retreatment in vitro: a method to evaluate changes in cell junctions and
in cell viability BOOK REVIEWS Prospects for use
of in vitro methods for assessment of human safety / Developments and
ethical considerations in toxicology / The ethics of animal and human
experimentation / Current standards in Europe for the care of non-human
primates in laboratories Volume
24, Number 6 CONTENTS EDITORIAL The use of prediction
models in validation studies: what should they predict? ECVAM NEWS & VIEWS LETTER FROM CAAT ARTICLES
The production of
avian (egg yolk) antibodies: IgY. NHIK 3025 cell culture:
a new in vitro test for phototoxicity screening. The comparative testing
of eight coded chemicals in the rat limb bud micromass and rat embryo
culture systems. Animal laboratory
exercises in medical school curricula. AROUND THE WORLD Abstracts of the main articles published in ALTEX Volume 13, 1996 EuroNICHE BOOK REVIEWS Alternativen zu tierexperimenten:
wissenschftliche herausforderung und perspektiven / Bioactive compound
design: possibilities for industrial use / Dermatotoxicology AUTHOR INDEX SUBJECT INDEX Volume
23, Number 1 CONTENTS EDITORIAL NEWS & VIEWS LETTER FROM CAAT PREFATORY NOTE ARTICLES Dorothy Hegarty and
the founding of FRAME: a personal recollection. The Fund for the Replacement
of Animals in Medical Experiments (FRAME): the first 25 years. Achieving the achievable:
a review of animals in politics. The role of the Home
Office Inspector. Reduction in animal
use 35 years after Russell & Burch's Principles of Humane Experimental
Technique. Animal models and
alternatives in the quality control of vaccines: are in vitro methods
or in vivo methods the scientific equivalent of the emperor's new clothes?
The development and
evaluation of in vitro tests by the FRAME Alternatives Laboratory. Toxicity testing with
hepatocytes: some methodological aspects. Reconstructed human
epidermis in vitro: an alternative to animal testing. The role of structure-activity
relationships and expert systems in alternative strategies for the determiniation
of skin sensitisation, skin corrosivity and eye irritation. Education and training:
a basis for the introduction of the Three Rs alternatives into animal
research. ECVAM Workshop Report
ICCVAM: US Ad Hoc
Interagency Coordinating Committee on Validation of Alternative Methods
CONFERENCE REPORTS CONFERENCE DIARY BOOK REVIEWS Culture of animal
cells: manual of basic techique / In vitro cultivation of animal cells
/ Animal theology / General and applied toxicology Volume
23, Number 2 CONTENTS EDITORIAL NEWS & VIEWS LETTER FROM CAAT ARTICLES Evaluation of the
immunotoxicity of antiretroviral drugs using an in vitro method for the
induction and measurement of a specific antibody response in human peripheral
blood lymphocytes. A multicompartmental
dynamic computer-controlled model simulating the stomach and small intestine.
The role of prevalidation
in the development, validation and acceptance of alternative methods.
ECVAM Workshop Report
Alternative methods
to animal testing: a Canadian Health Protection Branch perspective. Genetically modified
animals CONFERENCE DIARY BOOK REVIEWS Replenish the earth
/ Handbook of laboratory animal management and welfare / The keratinocyte
handbook / Keratinocyte methods / Origins of human cancer: a comprehensive
review
CONTENTS EDITORIAL NEWS & VIEWS ECVAM NEWS & VIEWS LETTER FROM CAAT PREFATORY NOTE ARTICLES The development of
the Three Rs concept. Responsible animal
research: a riff of Rs. The public debate
about animal experimentation. A new reductionism
for animal research. The third R: refinement.
Supply, coding and
distribution of samples for validation studies. Regulatory genotoxicity
testing: a critical appraisal. Transgenesis and animal
welfare. ECVAM Workshop Report
The integrated use
of alternative approaches for predicting toxic hazard. CONFERENCE DIARY BOOK REVIEWS Human tissue: ethical
and legal issues / Introduction to toxicology / Symposium proceedings:
animal care and use committees and alternatives / Archives of toxicology,
supplement 17: toxicology in transition / The monkey wars Volume
23, Number 4 CONTENTS EDITORIAL NEWS & VIEWS ECVAM NEWS & VIEWS LETTER FROM CAAT ARTICLES The Twelfth Congress
on In Vitro Toxicology of the Scandanavian Society for Cell Toxicology
Biological evaluation
of medical devices: a review of EU regulations, with emphasis on in vitro
screening for biocompatibility. Scientific validation:
a crucial and unavoidable prerequisite to the acceptability of new tests
and testing strategies. Gap junctional intercellular
communication and modulators of kinases and phosphatases. Side-specific toxic
effects on the membranes of cultured renal epithelial cells (A6). In vitro methods as
a tool in neurotoxicity studies. The reducing agent
dithiothreitol (DDT) increases expression of c-myc and c-fos proto-oncogenes
in human cells. Toxicity, clastogenicity
and genotoxicity of theophylline and pentoxifylline in mammalian cells
cultured in vitro. Defence mechanisms
protecting glial cell cultures against the toxicity of lead. The impact of computer-based
alternatives on the use of animals in undergraduate teachings: a pilot
study. Direct determination
of glutathione reductase in cells cultured in microtitre plates as a biomarker
for oxidative stress. The effects of carbocaine
hydrochloride on isolated porcine corneas in vitro: a comparison of opacity,
hydration and thickness. CONFERENCE DIARY BOOK REVIEWS European medicines
research / Research animal anesthesia and analgesia in surgery / Animal
cells as bioreactors / Methods in molecular biology Volume
23, Number 5 CONTENTS EDITORIAL The use of animals
for training surgeons ARTICLES Poor Model Man: Experimenting
on Chimpanzees. The First PACE Conference Chimpanzees biomedical
experiments: a question of efficacy. Difficulties with
animal models: chimpanzee research. Chimpanzees in AIDS
research. Chimpanzee medical
experiments: moral, legal and scientific concerns. Why is it unethical
to use chimpanzees in the laboratory. Moral issues in relation
to chimpanzee field studies and experiments. The Great Ape Project:
premises and implications. The work of Pro Primates
in laboratory. Present and future
prospects for using alternatives to chimpanzees in research. Animals, apes, men:
equally victims of vivisection. HIV infection: options
for control. The misuse of chimpanzees
in biomedical experiments. Cryopreservation of
rat and monkey liver slices. The evaluation of
pesticide ingredients and formulations in vitro and correlations with
in vivo data. Mouse whole-embryo
culture in serum diluted with Waymouth medium: a study of valproic acid
teratogenicity. The use of the cultured
bovine lens to measure the in vitro ocular irritancy of ketones and acetates.
ECVAM Workshop Reports
Nephrotoxicity testing
in vitro. BOOK REVIEWS Wildlife mammals as
research models / Animals and science in the twenty-first century Volume
23, Number 6 CONTENTS EDITORIAL Reduction, refinement
and replacement: the end of an era, new beginnings, and new challenges
ECVAM NEWS & VIEWS LETTER FROM CAAT PREFATORY NOTE ARTICLES On keeping your eyes
on the prize: Dorothy Hegarty and acceptance of the concept of replacement
of laboratory animal procedures in research, education and testing. The progress of humane
experimental techniques since 1959: a personal view. Computer simulation
in drug research. Cytotoxicity of biomaterials
-- basic mechanisms and in vitro test methods: a review. Determination of critical
cellular neurotoxic concentrations in human neuroblastoma (SH-SY5Y) cell
cultures. Advances in refinement
in animal experimentation over the past 25 years. Alternatives in Canada.
Benefits, necessity
and justification in animal research. ECVAM Workshop Reports
Screening chemicals
for reproductive toxicity: the current alternatives. The validation of
alternative test methods. What is SCAW? Abstracts of the main
articles published in ALTEX Volume 12 1995 CONFERENCE DIARY BOOK REVIEWS A guide to the laboratory
culture of human skin cells / Advances in drug metabolism in man / Alternatives
to animal experimentation SELECTED TITLES INDEX AUTHOR INDEX SUBJECT INDEX
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