RED DE BIOETICA
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Volume
22, Number 1 CONTENTS EDITORIAL NEWS & VIEWS ARTICLES Testing acute toxicity
in the embryo of zebrafish, Brachydanio rerio, as an alternative to the
acute fish test: preliminary results. The Galileo Data Bank
on toxicity testing with in vitro alternative methods. I. General structure.
Evaluation of the
EYTEX® system as a screening method for the ocular irritancy of chemical
products. CONFERENCE DIARY CONFERENCE REPORTS BOOK REVIEWS Volume
22, Number 2 CONTENTS EDITORIAL NEWS & VIEWS ARTICLES In vitro methods for
the assessment of L-cysteine conjugate toxicity. The Galileo Data Bank
on toxicity testing with in vitro alternative methods. II. Toxicology
profiles of 20 chemicals. Cell agglutinating
activity of A-gliadin-related synthetic peptides. COMMENT Defining cell viability
and cytotoxicity CONFERENCE REPORTS BOOK REVIEWS
Volume
22, Number 3 CONTENTS EDITORIAL NEWS & VIEWS ARTICLES Toxicity of 39 MEIC
chemicals to bioluminescent photobacteria (the BiotexTM test): correlation
with other test systems. The Eleventh Congress on In Vitro Toxicology of the Scandanavian Society for Cell Toxicology Hydrogen peroxide
stimulation of active sodium transport in isolated frog skin: indicative
of a possible prostaglandin interaction. Comparative cell toxicology:
the basis for in vitro toxicity testing. The neurotoxicity
of organic solvents studied using synaptosomes and neural cell cultures.
In vitro transformation
of C3H/10T1/2 and SHE cells by propylene oxide and epichlorohydrin. Inclusion of physicochemical
data in quantitative comparisons of in vitro and in vivo toxic potencies.
The effect of non-ionic
X-ray contrast media on glial cells in vitro. Effects of polyunsaturated
fatty acids on glial cell activation. A study using primary cultures.
COMMENT Clinical pharmacokinetics
in drug safety evaluation. BOOK REVIEWS
Volume
22, Number 4 CONTENTS EDITORIAL NEWS & VIEWS ECVAM NEWS & VIEWS ARTICLES ECVAM Workshop Report
Aquatic toxicology
in vitro: a brief review. NMR imaging of laboratory
mice at 2 Tesla: a non-invasive insight into normal anatomy. A mathematical model,
describing the kinetic behaviour of the thrombopoietic system in mice
and rats. COMMENT The APC report on
regulatory toxicity testing. First European Commission
report on statistics of animal use. CONFERENCE DIARY BOOK REVIEWS
Volume
22, Number 5 CONTENTS EDITORIAL NEWS & VIEWS ECVAM NEWS & VIEWS ARTICLES ECVAM Workshop Report
In vitro neurotoxicity
testing. The calorimetric-respirometric
ration: its potential as a cytotoxicity test. COMMENT IVTIP proposal on
future lines of research in in vitro toxicity testing. CONFERENCE DIARY CONFERENCE REPORTS BOOK REVIEWS
Volume
22, Number 6 CONTENTS EDITORIAL NEWS & VIEWS ECVAM NEWS & VIEWS LETTER FROM CAAT ARTICLES ECVAM Workshop Report
Fourth Meeting of
The Netherlands In Vitro Toxicology Group and The Netherlands Alternatives
to Animal Experiments Platform Induction of sister-chromatid
exchanges, micronuclei and gene mutations by indirectly acting promutagens
using human hepatoma cells as an activation system. Species-specific effects
of nitromethylene heterocycle insecticides on nicotinic receptors in locust
neurons and mouse N1E-115 and BC3H1 cells The use of porcine
proximal tubular cells for studying for studying nephrotoxicity in vitro:
Validation of the effects of culturing and cryopreservation. The Finkleman Preparation:
a computer simulation for teaching undergraduate students of pharmacology.
A comparison between
COMPACT and Hazardexpert evaluations for 80 chemicals tested by the NTP/NCI
rodent bioassay. The intestinal mucosa
of coeliacs in remission is unable to abolish the agglutinating activity
of gliadin peptides on K562(S) cells. COMMENT Report of the European
Parliamentary Committee on Energy, Research and Technology on the role
of ECVAM. CONFERENCE DIARY CONFERENCE REPORTS BOOK REVIEWS SELECTED TITLES Volume
21, Number 1 CONTENTS EDITORIAL NEWS & VIEWS ARTICLES Comparisons of xenobiotic-mediated
cytotoxicities in rat cultured hepatocytes and the V79 Chinese hamster
lung fibroblast cell line: can metabolically-activated hepatotoxins be
identified by selective cytotoxicity to hepatocytes? Multiple computer
automated structure evaluation methodology as an alternative to in vitro
eye irritation testing. First Meeting of CELLTOX
An in vivo/in vitro
study of allyl alcohol toxicity using enzyme inhibitors. In vitro systems for
the study of cereal proteins toxic in coeliac disease. K562. A human cellular
system capable of undergoing in vitro differentiation: measurement of
genotoxic parameters useful for cytotoxicity evaluation. Reductive activation
of carbon tetrachloride by human haemoglobin. Evaluation of the
cytotoxicity of the first 20 MEIC chemicals in two hepatoma cell lines
with different xenobiotic metabolism capacities. The use of the vitality
and chemotaxis of human polymorphonuclear leukocytes for the in vitro
estimation of the acute toxicity of the first ten chemicals from the MEIC
list. A European interlaboratory
evaluation study of an in vitro ocular irritation model (Skin2TM Model
ZK1100) using 15 chemicals and 3 shampoos. The evaluation of
a multi-endpoint cytotoxicity assay system. In vitro validation
of poly(ester-ether-ester) block copolymers as biomaterials. CONFERENCE REPORTS BOOK REVIEWS The use of animals
in research, development and testing / The brain in bits and pieces /
Immunology / Clinical immunotoxicology / In vitro methods of toxicology
/ Calculated risks: the toxicity and human health risks of chemicals in
our environment. Volume
21, Number 2 CONTENTS EDITORIAL NEWS & VIEWS ARTICLES The influence of animal
discomfort, human interest and scientific quality on the ethical acceptability
of a projected animal experiment as assessed with questionnaires. Evaluation of the
first ten MEIC chemicals in the Allium test. Toxicity of the first
ten MEIC chemicals to bacteria. Evaluation of the
cytotoxicity of the first ten MEIC chemicals in 3T3 mouse fibroblasts
with and without microsomal activation, using the neutral red assay. The Tenth Congress
on In Vitro Toxicology of the Scandanavian Society for Cell Toxicology
Use of toxicokinetics
in risk assessment based on in vitro data. Protein kinase C and
phagocytic activity in amitriptyline-exposed primary cultures of glial
cells. The use of several
leakage markers which enable platelet membrane damage and platelet activation
to be distinguished. Three-dimensional
growth of renal epithelial cells in vitro: a tool in toxicity testing.
An alternative test
using algal cultures for testing chemicals for toxicity. Use of a Syrian hamster
embryo (SHE) cell transformation for the in vitro testing of five pesticides.
Survival and function
of fibroblasts stored as stock cultures at a non-freezing temperature.
In vitro toxicity
testing using marine luminescent bacteria (Photobacterium phosphoreum):
the BiotoxTM test. Cytotoxicity of 28
MEIC chemicals to rat hepatocytes using two viability endpoints: correlation
with toxicity data in rat and man. Application of the
Ames genotoxicity assay and the bioluminescent toxicity assay in the testing
of urine samples. Of bacteria and men:
toxicity of 30 MEIC chemicals to bacteria and humans. Qualification of EYTEX®
data: a user's guide. Anticholinesterase
activity of aldicarb and carbofuran in neuron cultures. Quantification of
cytotoxicity by cell volume and cell proliferation. CONFERENCE DIARY CONFERENCE REPORTS BOOK REVIEWS SELECTED TITLES Volume
21, Number 3 CONTENTS EDITORIAL NEWS & VIEWS ARTICLES Assessment of the
functional integrity of hepatocytes: a brief review. The predictive potential
of a battery of toxicological tests for human acute toxicity, as evaluated
with the first 50 MEIC chemicals. Frog skin: a computer
simulation of experiments performed on frog skin in vitro to investigate
the epithelial transport of ions. Bovine pulmonary,
hepatic, and renal tissue: models for the study of mammalian C-S lyase
enzymes. Effects of benzoalkonium
chloride on pilocarpine-induced opacity in porcine isolated corneas. AROUND THE WORLD Government initiatives
to change the German Animal Protection Act CONFERENCE DIARY SOFTWARE REVIEW BOOK REVIEWS Computers in biomedicine
/ Isolated hepatocytes: preparation, properties and applications / Biology
now! Developing alternatives to animal experimentation / Toxicology of
the kidney / Man and mouse Volume
21, Number 4 CONTENTS EDITORIAL NEWS & VIEWS ARTICLES Magnetic resonance
imaging and spectroscopy: new noninvasive in vivo approaches in toxicology
research. Critical evaluation
of an agarose diffusion method for the assessment of eye irritancy. Third Meeting of The
Netherlands In Vitro Toxicology Group and The Netherlands Alternatives
to Animal Experiments Platform Use of cloned G-protein-coupled
receptor in the in vitro screening of psychotropic compounds. Uptake of organic
chemicals across fish gills: alternatives to the use of fish populations.
Isolation and culture
of proximal tubular cells from porcine kidney. Human liver slices
express the same lidocaine biotransformation rate as isolated human hepatocytes.
Cytotoxicity studies
of anchorage-independent LS-L-929 mouse fibroblasts using membrane integrity,
ATP content and ATP/ADP ration as determinants: including the xenobiotic
effects of components in an experimental shampoo formulation. Similarities in the
mechanisms of antibacterial activity (MicrotoxTM assay) and toxicity to
vertebrates. Neutral red uptake,
cellular growth and lysosomal function: in vitro effects of 24 metals.
SHORT NOTE Preliminary findings
of an in vitro assay based on human complement activation for the detection
of chemicals with phototoxicity potential. Abstracts of the main
articles published in ALTEX Volume 18 (March 1993) and Volume 19 (September
1993) BOOK REVIEWS Renal disposition
and nephrotoxicity of xenobiotics / In vitro alternatives to animal pharmacotoxicology
/ Refinement and reduction in animal testing
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