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Volume 20, Number 1 CONTENTS EDITORIAL NEWS & VIEWS ARTICLES Hepatocytes in primary
culture: an alternative to LD50 testing? Validation of a predictive model
by multivariate analysis. Toxicity of sodium
dodecyl sulphate and other detergents in cultures of human oral mucosa
epithelium. Two procedures for
the prediction of acute toxicity (LD50) from cytotoxicity data. Cell culture methods
to evaluate the biocompatibility of implant materials. Functional alterations
of endothelial cells cultured in vitro in contact with biomaterials. In vitro cytotoxic
effects of extracellular ATP. Renal cortical slices:
an in vitro model for kidney metabolism and toxicity. Use of cultured hepatoma
cell lines in the assessment of aldehyde metabolism. Inhibitions of growth,
morphological and morphometrical changes induced by amido-anthraquinone
derivatives in NCTC 2544 and HeLa cells. In vitro reconstitution
of differentiated human epithelia. The micronucleus test
in cultured mammalian cells and in Mytilus gill tissue. Photoprotection exerted
by sunscreens in a human cell line after UV damage. Lymphocyte transformation
tests in workers with occupational exposure to spiramycin. Evaluation of toxicity
testing of 20 MEIC chemicals on Hep-2 cells using two viability endpoints.
BaP metabolism and
DNA-adduct formation in cultured human lymphocytes treated in vitro with
BaP and (-)-BaP-7,8-dihydrodiol. A new in vitro model
for predicting the toxicity of cosmetic products. Application of the
EYTEXTM system to the evaluation of cosmetic products and their ingredients.
SHORT NOTE Development of potential
alternatives to the Draize test: the CTFA Evaluation of Alternatives Program.
Phase II: a review of amterials and methods. BOOK REVIEWS Measuring cell adhesion
/ Monographs on pathology of laboratory animals: chemopoietic system /
Living resources for biotechnology: animal cells / Developments in biotherapy:
from clone to clinic / Human cancer in primary culture: a handbook / Methods
in molecular biology: animal cell culture / Immunological recognition
/ Lives in the balance: the ethics of using animals in biomedical research
/ Interactions among the central nervous system, neuroendocrine and immune
systems / Current communications in cell and molecular biology: apoptosis
/ A practical approach to toxicological investigations Volume
20, Number 2 CONTENTS EDITORIAL NEWS & VIEWS ARTICLES The Ninth Congress
on In Vitro Toxicology of the Scandanavian Society for Cell Toxicology
Heavy metal ions,
cytotoxicity and gap junctional intercellular communication in Syrian
hamster embryo cells. Electrophysiological
measurements of a toad renal epithelial line (A6) as an assay for predicting
ocular eye irritancy. Effects of the first
twenty MEIC reference chemicals on viability, glucose consumption and
spontaneous contractility of primary cultured rat skeletal muscle cells.
Evaluation of cytotoxicity
of the first twenty MEIC chemicals by using haemolysis of human erythrocytes
as an endpoint. Modification of the
FRAME kenacid blue method for cytotoxicity tests on volatile materials.
Effects of carbon
tetrachloride on perfused cultures of hepatic and neuronal cells. Evaluation of the
relevance of selected in vitro test systems for acute systemic toxicity.
Changes in astroglial
cell volume after exposure to HgCl2 or CH3HgCl. Paraquat alters growth,
DNA and protein synthesis in lung epithelial cell and fibrobalst cultures.
The possible use of
isolated human platelets in in vitro cell toxicology. Use of external metabolising
systems in the neutral red assay. Toxicity of glycols
and allyl alcohol evaluated by means of co-cultures of microcarrier-attached
rat hepatocytes and BALB/C 3T3 mouse fibroblasts. The use of microglia
activation in the evaluation of neurotoxicity. Cytotoxicity of continuous
ambulatory peritoneal dialysis (CAPD) solutions. A biocompabtibility study
involving human polymorphonuclear granulocytes rather than laboratory
animals. Estimation of toxicity
of chemicals from the MEIC list by colony radial growth rate measurements
in the fungus Geotrichum candidum. Long-term cytotoxicity
testing of the first twenty MEIC chemicals by the determination of the
protein content in human embryonic lung cells. The neurotoxicity
of organic solvents, studied with in vitro models. The use of Artemia
slaina in toxicity testing. Time-lapse phase-contrast
microphotography of cell populations as a basis for improvement. A simple method for
cytotoxicity studies of non-hydrosoluble substances. Possible application
as an alternative to the Draize test for cosmetics and toiletries. A human epidermal
model that can be used in automated ultiple endpoin assay. Inhibition of protein
synthesis after exposure of Caco2 cells to heavy metals. COMMENT Animal research within
an ethical framework. BOOK REVIEWS Understanding cell
toxicology: principles and practice Volume
20, Number 3 CONTENTS EDITORIAL NEWS & VIEWS ARTICLES ZEBET's data bank
and information service on alternatives to the use of experimental animals
in Germany. The use of basal cytotoxicity
and target organ toxicity tests in hazard identification and risk assessment.
The haemocompatibility
of biomaterials in vitro: investigations on the mechanism of the whole-blood
clot formation test. Cyst-based toxicity
tests. IV. The potential of ecotoxicological tests for the prediction
of acute toxicity in man as evaluated on the first ten chemicals of the
MEIC programme. ECITTS: an integrated
approach to the application of in vitro test systems to the hazard assessment
of chemicals. Third SPTC Meeting
on Alternatives to Ocular Irritation The agarose overlay
method as a screening approach for ocular irritancy: application to cosmetic
products. Cytotoxicity of non-hydrosoluble
substances towards human skin fibroblasts cultured on microporous membrane:
a model for the study of ocular irritancy potential. Prediction of eye
irritation potential of surfactants using the SIRC-NRU cytotoxicity test.
Contributions of physicochemical
properties to the evaluation of ocular irritation. Evaluation of the
EYTEXTM system as a screening method for ocular tolerance: application
to raw materials and finished products. Ocular irritation:
present cell culture models and perspectives. The eye (rabbit/human):
parameters to be measured in the field of ocular irritation. AROUND THE WORLD CEC collaborative
study on the evaluation of alternative methods to the eye irritation test.
CONFERENCE DIARY BOOK REVIEWS Principles and methods
of toxicology -- 2nd edition / Animal welfare and the law / Principles
of clinical toxicology -- 2nd edition / The well-being of agricultural
animals in biomedical and agricultural research Volume
20, Number 4 CONTENTS EDITORIAL NEWS & VIEWS ARTICLES The effects on porcine
isolated corneas of the addition of various preservatives to befunolol-HCl
solutions. In vitro mechanistic
toxicology evaluation of the antibiotic, paldimycin sodium, in Chang liver
cells. An interactive computer
simulation of experiments to teach the principles of nutrient transport
in the small intestine. The scientific basis
of the EYTEXTM system. Relationships between
cellular toxicity, the maximum tolerated dose, lipophilicity and electrophilicity.
COMMENT In vitro test validation:
the winds of change. In vitro test validation:
no room for conflict with "mechanistic" studies. In vitro test validation
and regulatory animal testing: a house built on sand versus a house of
cards? In vitro toxicity
testing: refining our objectives. AROUND THE WORLD Abstracts of the main
articles published in ALTEX volume 16 (March 1992) and volume 17 (September
1992). Tissue specific toxicity:
biochemical mechanisms / Hepatic metabolism and disposition of endo- and
xenobiotics / Principles of biochemical toxicology -- second edition /
Principles and practice of immunotoxicology / In vitro toxicity testing:
applications to safety evaluation / Animals and alternatives in toxicology:
present status and future prospects / Principles of humane experimental
technqiues / Issues: animal experiments Intestinal absorption
SELECTED TITLES SELECTED TITLES INDEX SUBJECT INDEX AUTHOR INDEX Volume
19, Number 1 CONTENTS EDITORIAL NEWS & VIEWS ARTICLES ELISA for guinea-pig
IgG1: An alternative to the PCA test for relative allergenicity. Italian Tissue Culture
Meeting Changes in the concentrations
of deoxynucleotides in human lymphocytes treated in vitro with genotoxic
agents. Induction of cytoplasmic
vacuolation by two alkyl-diamine compounds. Toxicity of ethylene-bis-dithiocarbamates
(EBDCs) in a human neuroblastoma cell line. Computerised image
analysis of nuclear enlargement assay in HeLa cells. Bioactivation and
toxicity of two anthraquinones in V79 chinese hamster cells. Effects of 4-hydroxynonenal
on microtubular system of normal and transformed fibroblasts. ATP and protein synthesis
assays to evaluate the toxicities of preservatives in vitro. Exogenous histidine
as a co-factor which exacerbates the toxicity of hydrogen peroxide in
cultured mammalian and bacterial cells. In vitro models for
biochemical investigations on programmed cell death. An in vitro model
for studying oxidative damage and protective substances in human cells.
Oxidant-induced inhibitions
of DNA synthesis. Effects of neutral
shampoos on cultures of human fibroblasts. Teratogenicity testing
in vitro: Post-implantation whole-embryo culture. A preliminary investigation
into the opacifying effects in vitro of compounds with varying numbers
of nitrogen-containing groups using isolated porcine corneas. Improved housing of
mice, rats and guinea-pigs: A contribution to the refinement of animal
experiments. Animals and alternatives in toxicology: Present status and future prospects (The Second Report of the FRAME Toxicity Committee). COMMENT In Vitro Test Validation.
AROUND THE WORLD CONFERENCE DIARY CONFERENCE REPORT BOOK REVIEWS Oncogenes and the
molecular origins of cancer / Small animal oral medicine and surgery /
Molecular medicinal biochemistry / Vaccines '90 / Is animal experimentation
justifiable? / New trends in genetic risk assessment / Managing the behaviour
of animals / Canine orthopaedics / Theory and application of microbiological
assay / Basic science in toxicology / Methods and evaluation of in vitro
models of antimicrobial chemotherapy / Ecotoxicology: the study of pollutants
in ecosystems / The emergence of bacterial genetics Volume
19, Number 2 CONTENTS EDITORIAL NEWS & VIEWS ARTICLES Structure-activity
relationships for unsaturated dialdehydes. V. Estimation of the lipophilicity
of nineteen sesquiterpenoid unsaturated dialdehydes, and determination
of their chemical stability in three in vitro assay media. The Eighth Congress
on In Vitro Toxicology of the Scandinavian Society for Cell Toxicology
The use of human lymphocytes
for the in vitro estimation of acute toxicity of ten chemicals from the
MEIC list. Repeated exposure
of glial cells in primary cultures to amitriptyline and diazepam. Anomalous dose-response
relationship due to association colloidal behaviour of soluble amphiphilic
compounds. A method based on
the roller chamber technique for determination of CO2 production in cultured
cells: Effects of acrylamide in neuroblastoma N1E115 cultures. Toxicity testing by
means of cryopreserved bovine spermatozoa. The use of primary
cultured rat hepatocytes for the assessment of xenobiotic effects on biotransformation.
Direct and indirect
assessment of the aneuploidy-inducing potency of organotin compounds.
Mercuric chloride
affects morphology and thymidine incorporation into DNA in astroglial
cells in culture. Testing of polymer
materials: what methods should be used? Validation of in vitro
cytotoxicty tests -- past and present strategies. Factors important
to the quality of cell culture toxicology. On establishing the
safety of cosmetic ingredients and products produced and/or marketed within
the European Economic Community. Effects of high pressure
and metal salts on cell growth. Metabolic studies
in human subjects. The use of an opacitometer
to compare the in vitro cornea opacifying effects of timolol with and
without benzalkonium chloride. COMMENT The use of computers
to reduce animal experimentation in pharmacology. BOOK REVIEWS Primate responses
to environmental change / Guidelines for the well-being of rodents in
research / Problems to animal behaviour / Political theory and animal
rights Volume
19, Number 3 CONTENTS EDITORIAL NEWS & VIEWS ARTICLES Comments on labelling
related to the animal testing of cosmetic ingredients and products manufactured
and/or marketed within the European Economic Community. Effects of oxybarbiturates
on fern spore germination and gametophyte development. Computer simulated
demonstration of the actions of drugs on isolated perfused mammalian heart
(Langendorff preparation). In vitro cytotoxicity
tests on cultured human skin fibroblasts to predict the irritation potential
of surfactants. Correlation between
in vitro cytotoxicity and octanol/water partition coefficient of 29 substances
from the MEIC programme. The opacifying effects
of carteolol HCl and benzalkonium chloride on porcine isolated corneas.
An in vitro cytotoxicity
assay using rat hepatocytes and MTT and coomassie blue dye as indicators.
BOOK REVIEWS Biotransformations
/ The importance of animal experimentation for safety and biomedical research
/ Biology of mammalian germ cell mutagenesis AROUND THE WORLD Brussels Symposium
on Alternative Methods in Pharmaco-toxicological Research
Volume 19, Number 4 CONTENTS EDITORIAL NEWS & VIEWS ARTICLES Can the in vivo maximum
tolerated dose be predicted using in vitro techniques? A working hypothesis.
Polyclonal IgY antibodies
from chicken egg yolk -- an alternative to the production of mammalian
IgG type antibodies in rabbits. Chemical contamination
suspected in cytotoxic effects of incubators on BALB 3T3 cells. Complementation in
the development, validation and use of non-animal test batteries, with
particular reference to ocular irritancy. The current status
of in vitro test validation (evaluation) in the United States. Abstracts of the main articles published in "Alternativen zu Tierexperimenten" (ALTEX) Volume 13 (December 1990), Volume 14 (April 1991) and Volume 15 (September 1991). Symposium of the Dutch
In Vitro Toxicology Society CONFERENCE DIARY BOOK REVIEWS Dermatotoxicology
-- fourth edition / Trends in animal cell culture technology. SELECTED TITLES INDEX SUBJECT INDEX AUTHOR INDEX
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